Mesothelioma – The Biological Behavior

Mesothelioma biological behavior can be predicted by their gross look, shape and structures. They commonly solitary, discrete masses, generally benign and where they grow diffusely are usually malignant. Mesothelioma is a tumor which emerge from mesothelial lining of serous cavities. It often cover lungs (the pleural cavity) , rarely, in coverings of abdomen (peritoneal cavity) and covering the heart (pericardial sac).

There are two types of mesothelioma biological behavior, benign and solitary. Benign or solitary is also called pleural fibroma. Asbestos exposure do not play a role on the etiology of benign mesothelioma. This behavior consists of a solitary, circumscribed, small, firm mass and less than one inch diameter in general. By cutting the surface, you can see dense fibrous tissue. Predominantly of collage fibers and reticulin with interspersed fibroblasts are composing the tumor. Benign mesothelioma is associated with systemic syndrome of osteoarthropathy or hypoglycemia. Generally, the removal of the tumor is curative.


Mesothelioma – Malignant or diffuse.

The maglinant tumor has a high risk of mortality. The case is rare and like other asbestos related disease, this tumor is also take 20-40 years to be detected. Almost 90% of maglinant cases are caused by asbestos exposure.



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